How Psilocybin Can Rewire Our Brain Its Therapeutic Benefits Its Risks Huberman Lab Podcast

In this episode I discuss what psilocybin is chemically and how it works at the cellular and neural circuit level to trigger neuroplasticity which is our brain s ability to rewire itself in ways that lead to long-lasting shifts in our emotional cognitive and behavioral patterns and abilities I discuss the emerging clinical trial evidence for the use of psilocybin in the treatment of depression addictions and other psychiatric challenges I explain the typical duration and phases of a psilocybin journey the different categories of dosages often used and I explain the importance of set setting and support when using psychedelics I explain which groups of people place themselves at great risk by taking psilocybin as well as groups that could benefit and I highlight the rapidly changing legal and medical landscape around psilocybin This episode is a thorough exploration of psilocybin from the scientific and clinical literature perspective and ought to be of interest to anyone curious about psilocybin mental health neuroplasticity and or psychedelics more generally HubermanLab Science Thank you to our sponsors AG1 Athletic Greens a https 3A 2F 2Fathleticgreens com 2Fhuberman a Eight Sleep a https 3A 2F 2Feightsleep com 2Fhuberman a ROKA a https 3A 2F 2Froka com 2Fhuberman a HVMN a https 3A 2F 2Fhvmn com a code Huberman LMNT a https 3A 2F 2Fdrinklmnt com 2Fhuberman a Supplements from Momentous a https 3A 2F 2Fwww livemomentous com 2Fhuberman a Social Website Instagram a https 3A 2F 2Fwww instagram com 2Fhubermanlab a Twitter a https 3A 2F 2Ftwitter com 2Fhubermanlab a Facebook a https 3A 2F 2Fwww facebook com 2Fhubermanlab a LinkedIn a https 3A 2F 2Fwww linkedin com 2Fin 2Fandrew-huberman a Website a https 3A 2F 2Fhubermanlab com a Newsletter a https 3A 2F 2Fhubermanlab com a neural-network Articles The neural basis of psychedelic action a https 3A 2F 2Fgo nature com 2F3VInMlE a The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers a https 3A 2F 2Fbit ly 2F3VW8iL7 a Increased low-frequency brain responses to music after psilocybin therapy for depression a https 3A 2F 2Fbit ly 2F3LKj6XK a Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression a https 3A 2F 2Fbit ly 2F42c7y6x a Brief structured respiration practices enhance mood and reduce physiological arousal a https 3A 2F 2Fbit ly 2F3wEvGRf a Therapeutic use of psilocybin Practical considerations for dosing and administration a https 3A 2F 2Fbit ly 2F3HPHLZM a Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo a https 3A 2F 2Fbit ly 2F3HQ8J3z a Psychedelics and Neuroplasticity A Systematic Review Unraveling the Biological Underpinnings of Psychedelics a https 3A 2F 2Fbit ly 2F44Gpwjx a Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression a https 3A 2F 2Fbit ly 2F3pjvu9N a Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder a https 3A 2F 2Fbit ly 2F3sFSGMM a The costs and benefits of psychedelics on cognition and mood a https 3A 2F 2Fbit ly 2F3NNyEwI a Other Resources The Physiological Sigh a https 3A 2F 2Fyoutu be 2FrBdhqBGqiMc a Dr Matthew Johnson Psychedelic Medicine a https 3A 2F 2Fhubermanlab com a dr-matthew-johnson-psychedelic-medicine Timestamps 00 00 00 Psilocybin Legal Considerations 00 08 32 Sponsors Eight Sleep ROKA HVMN 00 12 00 Psilocybin Becomes Psilocin in the Gut Serotonin 00 17 00 The Serotonin 2A Receptor Therapeutic Outcomes SSRIs vs Psilocybin 00 21 40 Serotonin Receptor Expression Visual Hallucinations Eyes Closed 00 27 21 Safety Cautions for Specific Patient Populations 00 29 13 Sponsor AG1 Athletic Greens 00 30 28 Psilocybin Magic Mushrooms Dosing Micro-Dosing Heroic Doses 00 36 21 Psychedelic Journey Set Setting Support 00 43 43 Music the Psilocybin Journey Duration of Effects 00 48 58 Psilocybin the Brain Subjective Experiences Perception 00 58 36 Sponsor LMNT 00 59 48 Brain Networks Therapeutic Outcomes 01 05 23 Creativity Music Emotionality Psychedelic Journeys 01 12 39 Depression Psychedelics as Neuroplasticity Wedge 01 16 53 Positive Psychedelic Journeys Unity Oceanic Boundlessness 01 25 23 Bad Trips Anxiety Physiological Sighs 01 32 57 Therapeutic Use of Psilocybin 01 36 11 Neuroplasticity Structural Brain Changes Psilocybin 01 48 08 Psychedelics Therapeutic Breakthroughs Depression 01 56 37 Combining Psilocybin Therapy Talk Therapy Antidepressant Effects 02 03 11 Psilocybin Experience Mental Health 02 06 42 Zero-Cost Support YouTube Feedback Spotify Apple Reviews Sponsors Momentous Neural Network Newsletter Social Media Title Card Photo Credit Mike Blabac - a https 3A 2F 2Fwww blabacphoto com a Disclaimer a https 3A 2F 2Fhubermanlab com a disclaimer

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