The Science of MDMA Its Therapeutic Uses Benefits Risks Huberman Lab Podcast

In this episode I discuss methylenedioxymethamphetamine MDMA which is also commonly known as ecstasy or molly including how it works in the brain to cause short- and long- term-shifts in emotional processing and its clinical applications for the treatment of post-traumatic stress disorder PTSD alcohol and other substance-use addictions I discuss the neuronal mechanisms for how MDMA elevates mood empathy motivation social engagement and reduces threat detection and how these effects can synergistically support talk therapy I also explain the ongoing debate about the potential neurotoxicity of MDMA myths about the origins and treatments for post-MDMA crash the evolving legal landscape around MDMA use for clinical purposes and I caution recreational users about the extremely dangerous additives e g fentanyl now commonly found in black market MDMA This should be of interest to those curious about MDMA neuropharmacology the origins of emotional processing in the brain empathy PTDS neuroplasticity mental health and psychiatry HubermanLab Science Thank you to our sponsors AG1 a https 3A 2F 2Fdrinkag1 com 2Fhuberman a Helix Sleep a https 3A 2F 2Fhelixsleep com 2Fhuberman a ROKA a https 3A 2F 2Froka com 2Fhuberman a HVMN a https 3A 2F 2Fhvmn com 2Fhuberman a LMNT a https 3A 2F 2Fdrinklmnt com 2Fhuberman a Momentous a https 3A 2F 2Flivemomentous com 2Fhuberman a Social Website Instagram - a https 3A 2F 2Fwww instagram com 2Fhubermanlab a Twitter - a https 3A 2F 2Ftwitter com 2Fhubermanlab a Facebook - a https 3A 2F 2Fwww facebook com 2Fhubermanlab a TikTok - a https 3A 2F 2Fwww tiktok com 2F 40hubermanlab a Website - a https 3A 2F 2Fhubermanlab com a Newsletter - a https 3A 2F 2Fhubermanlab com a neural-network Articles A Conserved Role for Serotonergic Neurotransmission in Mediating Social Behavior in Octopus a https 3A 2F 2Fbit ly 2F3oV8zSl a Effects of MDMA on sociability and neural response to social threat and social reward a https 3A 2F 2Fbit ly 2F3NlOYUC a The Effects of Acutely Administered 3 4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level Dependent Resting State Functional Connectivity a https 3A 2F 2Fbit ly 2F42yMEhl a Distinct neural mechanisms for the prosocial and rewarding properties of MDMA a https 3A 2F 2Fbit ly 2F3NlNERM a Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans a https 3A 2F 2Fbit ly 2F42AF6e0 a RETRACTED Severe Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA Ecstasy a https 3A 2F 2Fbit ly 2F3J9PTVU a Science forced to retract article on ecstasy a https 3A 2F 2Fbit ly 2F3oRRpVM a Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs a https 3A 2F 2Fbit ly 2F3P93gcM a MDMA-assisted therapy for severe PTSD a randomized double-blind placebo-controlled phase 3 study a https 3A 2F 2Fgo nature com 2F3WqI2Zd a The effects of MDMA-assisted therapy on alcohol and substance use in a phase 3 trial for treatment of severe PTSD a https 3A 2F 2Fbit ly 2F42wqeNP a Books PIHKAL A Chemical Love Story a https 3A 2F 2Famzn to 2F45ZY80w a Trauma The Invisible Epidemic a https 3A 2F 2Famzn to 2F45VdgfA a The Body Keeps the Score a https 3A 2F 2Famzn to 2F3XgH5Dz a Other Resources Multidisciplinary Association for Psychedelic Studies MAPS a https 3A 2F 2Fmaps org a Participate in a MAPS trial a https 3A 2F 2Fmaps org a take-action participate-in-trial Huberman Lab episode on psilocybin a https 3A 2F 2Fbit ly 2F43yP80G a Huberman Lab episode on psychedelics for mental health a https 3A 2F 2Fbit ly 2F3NqC3Rz a Huberman Lab episode on dopamine mindset drive a https 3A 2F 2Fbit ly 2F3IqQzVb a Huberman Lab episode on leveraging dopamine a https 3A 2F 2Fbit ly 2F3P3dCuD a Timestamps 00 00 00 MDMA Ecstasy 00 04 37 Sponsors Helix Sleep ROKA HVMN 00 08 18 MDMA History Synthesis Legality 00 14 45 MDMA Methamphetamine Meth Dopamine Serotonin 00 23 30 MDMA vs Psychedelics vs Ketamine 00 26 54 MDMA Serotonin 1B Receptor Subjective Feelings Trauma 00 33 36 Sponsor AG1 00 34 51 Amygdala Threat Detection Pro-Social Behavior MDMA Dosages 00 45 48 Interoception MDMA Post-Traumatic Stress Disorder PTSD 00 52 36 Long-Term Effects Threat Detection PTSD 00 56 14 MDMA Social Connection Empathy Meth SSRIs 01 06 10 Sponsor LMNT 01 07 22 Oxytocin MDMA 01 16 10 Safety Neurotoxicity Recreational Use Caffeine Fentanyl 01 26 36 Is MDMA Neurotoxic Poly-Pharmacology Body Temperature 01 37 07 Post-MDMA Crash Prolactin P 5 P 01 43 07 PTSD Trauma Talk Therapy SSRIs 01 54 09 PTSD Treatment Talk Therapy MDMA 02 02 46 MDMA Addiction Dissociative PTSD Empathy 02 09 47 Side-Effects MDMA Efficacy Legality 02 15 22 Zero-Cost Support YouTube Feedback Spotify Apple Reviews Sponsors Momentous Social Media Neural Network Newsletter Title Card Photo Credit Mike Blabac - a https 3A 2F 2Fwww blabacphoto com a Disclaimer a https 3A 2F 2Fhubermanlab com a disclaimer

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