Understanding Conquering Depression

This episode I explain what major depression is at the biological and psychological level and the various treatments that peer-reviewed studies have revealed can help prevent and treat depression I explain the three major chemical systems that are altered in depression norepinephrine serotonin and dopamine I discuss genetic predispositions to depression and how stress thyroid hormone and cortisol play a role in many forms of depression I also discuss inflammation as a common feature of many depression symptoms I review 8 specific science-supported protocols for treating and avoiding depression including EPA fatty acids which have been shown to rival certain prescription treatments how exercise protects against depression studies of creatine adjusting dopamine balance and more I also discuss the results of ongoing clinical trials for ketamine and psilocybin for depression how these compounds work and finally I review how ketogenic diets can help in certain cases of depression especially treatment-resistant major depression For an updated list of our current sponsors please visit our website as previous sponsors mentioned in this podcast episode may no longer be affiliated with us a https 3A 2F 2Fwww hubermanlab com 2Fsponsors a Social Website Instagram a https 3A 2F 2Fwww instagram com 2Fhubermanlab a Threads a https 3A 2F 2Fwww threads net 2F 40hubermanlab a Twitter a https 3A 2F 2Ftwitter com 2Fhubermanlab a Facebook a https 3A 2F 2Fwww facebook com 2Fhubermanlab a TikTok a https 3A 2F 2Fwww tiktok com 2F 40hubermanlab a Website a https 3A 2F 2Fwww hubermanlab com a Newsletter a https 3A 2F 2Fwww hubermanlab com a newsletter Apple Podcasts a https 3A 2F 2Fapple co 2F3thCToZ a Spotify a https 3A 2F 2Fspoti fi 2F3PYzuFs a Links Review of EPAs for the Treatment of Depression - a https 3A 2F 2Fbit ly 2F2Wl15ti a Review of Creatine for the Treatment of Depression - a https 3A 2F 2Fwww mdpi com 2F520864 a Recent Study on the Clinical Use of Psilocybin for Treatment of Depression - a https 3A 2F 2Fbit ly 2F3sFSGMM a Timestamps 00 00 00 Mood Disorders Maintaining Mental Health Protocol 1 00 07 10 Sponsors 00 11 15 Major Depression 00 18 40 Anti-Self Confabulation 00 21 42 Autonomic Vegetative Symptoms of Depression 00 26 58 Norepinephrine Dopamine Serotonin 00 31 50 SSRIs Prozac Zoloft etc Selective Serotonin Reuptake Inhibitors 00 37 00 Epinephrine Motor Functions Dopamine Motivation Craving Serotonin Emotions 00 39 33 Physical Emotional Pain are Linked Substance P 00 41 50 Hormones Depression Thyroid Cortisol 00 46 50 Genetic Susceptibility to Depression Impact of Stress 00 50 50 Understanding Biological Mechanism Is Key Recipes versus Skills 00 52 50 Tools for Dealing with Depression Logic Implementation Protocol 2 00 56 25 Brain Inflammation Mental State Cytokines Prostaglandins etc 00 59 20 Protocol 3 Essential Fatty Acids Omega-3 EPAs Eicosapentaenoic Acid 01 02 50 How EPAs Help Offset Depression Serotonin Synthesis Kynurenine Quinolinic Acid 01 05 25 Protocol 4 How Exercise Offsets Depression 01 11 44 Protocol 5 Creatine Monohydrate Forebrain Function NMDA receptors 01 20 30 Protocol 6 Ketamine PCP Prescription-Only NMDA-Receptor Function 01 33 08 Protocol 7 Psychedelics In Clinical Trials for Major Depression Psilocybin 01 47 00 Protocol 8 Ketogenic Diet GABA Gamma-Aminobutyric Acid 01 54 50 Summary of Protocols Covered 02 00 10 Support Additional Resources Depression HubermanLab Dopamine Title Card Photo Credit Mike Blabac - a https 3A 2F 2Fwww blabacphoto com a Disclaimer a https 3A 2F 2Fwww hubermanlab com a disclaimer

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