Dr David Sinclair The Biology of Slowing Reversing Aging

In this episode I am joined by Dr David Sinclair tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity Dr Sinclair is also the author of the book Lifespan Why We Age Why We Don't Have To and the host of the Lifespan Podcast which launches January 5 2022 In this interview we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process We discuss fasting and supplementation with resveratrol NAD metformin and NMN We also discuss the use of caffeine exercise cold exposure and why excessive iron load is bad for us We discuss food choices for offsetting aging and promoting autophagy clearance of dead cells And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age We also discuss the future of longevity research and technology This episode includes lots of basic science and specific actionable protocols right down to the details of what to do and when By the end you will have in-depth knowledge of the biology of aging and how to offset it HubermanLab DavidSinclair Longevity Thank you to our sponsors ROKA - a https 3A 2F 2Fwww roka com 2Fhuberman a InsideTracker - a https 3A 2F 2Fwww insidetracker com 2Fhuberman a Magic Spoon - a https 3A 2F 2Fwww magicspoon com 2Fhuberman a Dr David Sinclair Links Lifespan Podcast a https 3A 2F 2Flifespanpodcast com a Twitter a https 3A 2F 2Ftwitter com 2Fdavidasinclair a Instagram a https 3A 2F 2Fwww instagram com 2Fdavidsinclairphd 2F a YouTube a https 3A 2F 2Fwww youtube com 2Fdavidsinclairpodcast a Lifespan book a https 3A 2F 2Famzn to 2F47MLimC a Aging Test Waitlist a https 3A 2F 2Fwww tallyhealth com a Harvard Lab Website a https 3A 2F 2Fsinclair hms harvard edu a Our Patreon page a https 3A 2F 2Fwww patreon com 2Fandrewhuberman a Supplements from Thorne a http 3A 2F 2Fwww thorne com 2Fu 2Fhuberman a Social Instagram - a https 3A 2F 2Fwww instagram com 2Fhubermanlab a Twitter - a https 3A 2F 2Ftwitter com 2Fhubermanlab a Facebook - a https 3A 2F 2Fwww facebook com 2Fhubermanlab a Website - a https 3A 2F 2Fhubermanlab com a Newsletter - a https 3A 2F 2Fhubermanlab com a neural-network Timestamps 00 00 00 Dr David Sinclair Harvard Medical School 00 03 30 ROKA InsideTracker Magic Spoon 00 07 45 Aging as a Disease vs Longevity Anti-Aging 00 10 23 What Causes Aging The Epigenome 00 15 53 Cosmetic Aging 00 17 15 Development Never Stops Horvath Clock 00 20 12 Puberty Rate as a Determinant of Aging Rate 00 23 00 Fasting Hunger Food Choices 00 32 44 Fasting Schedules Long Fasts Macro Autophagy 00 34 50 Caffeine Electrolytes 00 35 56 Blood Glucose the Sirtuins mTOR 00 37 55 Amino Acids Leucine Pulsing 00 44 35 Metformin Berberine 00 50 29 Resveratrol Wine 00 53 20 What Breaks a Fast 00 56 45 Resveratrol NAD NMN NR Dosage Timing 01 09 10 Are Artificial Sweeteners Bad for Us 01 12 04 Iron Load Aging 01 15 05 Blood Work Analysis 01 19 37 C-Reactive Protein Cholesterol Serum Dietary 01 26 02 Amino Acids Plants Antioxidants 01 33 45 Behaviors That Extend Lifespan Testosterone Estrogen 01 40 35 Neuroplasticity Neural Repair 01 46 19 Ice Baths Cold Showers Metabolic Winter 01 48 07 Obesity How It Accelerates Aging GnRH 01 52 10 Methylation Methylene Blue Cigarettes 01 56 17 X-Rays 01 59 00 Public Science Education Personal Health 02 05 40 The Sinclair Test You Can Take a www doctorsinclair com a 02 08 13 Zero-Cost Support Resources Sponsors Patreon Supplements Instagram The Huberman Lab Podcast is for general informational purposes only and does not constitute the practice of medicine nursing or other professional health care services including the giving of medical advice and no doctor patient relationship is formed The use of information on this podcast or materials linked from this podcast is at the user s own risk The content of this podcast is not intended to be a substitute for professional medical advice diagnosis or treatment Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions Title Card Photo Credit Mike Blabac - a https 3A 2F 2Fwww blabacphoto com a Audio Engineering Joel Hatstat at High Jump Media

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