The Science of How to Optimize Testosterone Estrogen

This episode I discuss the hormones testosterone and estrogen and how they impact the brain body and behavior at ages after puberty I also discuss how various behaviors such as exercise resistance and endurance training and sex or observing sex impact these hormones and their levels I ask what specifically is it about such activities that impact testosterone and estrogen the resounding theme is that when our nervous system is activated in particular ways it drives our endocrine system and vascular system to activate or repress certain hormone networks in predictable ways I also discuss peer-reviewed studies and protocols addressing at a mechanistic level how light cold and heat and respiration breathing can positively or negatively impact testosterone and estrogen And we discuss specific supplements and compounds that peer-reviewed studies illustrate can adjust testosterone and estrogen levels by changing their binding to other proteins by raising them directly or by changing other hormones released from the brain and pituitary I discuss optimization in the normal reference ranges for these hormones and I discuss pheromones apnea menstrual cycles menopause and andropause As always a mix of basic science biological mechanisms and tools and protocols are discussed Note Future episodes will focus on the science of prescription hormone replacement therapies the science of hormone-based birth control and the role of testosterone estrogen and other compounds in fertility athletic performance and recovery HubermanLab Testosterone Estrogen Thank you to our sponsors Four Sigmatic - a https 3A 2F 2Ffoursigmatic com 2Fhuberman a Blinkist - a https 3A 2F 2Fblinkist com 2Fhuberman a Theragun - a https 3A 2F 2Ftheragun com 2Fhuberman a Bloodwork sponsor InsideTracker - a https 3A 2F 2Finsidetracker com 2Fhuberman a Supplements from Thorne a http 3A 2F 2Fwww thorne com 2Fu 2Fhuberman a Social Website Instagram a https 3A 2F 2Fwww instagram com 2Fhubermanlab a Twitter a https 3A 2F 2Ftwitter com 2Fhubermanlab a Facebook a https 3A 2F 2Fwww facebook com 2Fhubermanlab a TikTok a https 3A 2F 2Fwww tiktok com 2F 40hubermanlab a LinkedIn a https 3A 2F 2Fwww linkedin com 2Fin 2Fandrew-huberman a Website a https 3A 2F 2Fhubermanlab com a Newsletter a https 3A 2F 2Fhubermanlab com a neural-network References Examine a https 3A 2F 2Fexamine com a Behavioral Endocrinology by Nelson and Kriegsfeld 5th Ed Timestamps 00 00 00 Introduction 00 05 50 Hormone Optimization 00 07 00 Salutogenesis A Powerful Way to Conceptualize Health 00 10 03 Estrogen and Testosterone Sources Levels Ratios 00 15 46 The Power of Competition Plus Anxiety Persistence Dopamine 00 20 58 Testosterone Libido Pre-Ovulation 00 21 48 Estrogen Sexual Receptivity Libido In Males 00 23 10 How Sex Behavior Impacts Testosterone Observing vs Actual vs Abstinence 00 26 46 Testosterone Prolactin Sex Seeking vs Pair Bonding 00 27 30 DHEA dehydroepiandrosterone Effects on Levels Ratios 00 28 45 Behaviors That Decrease Testosterone Cortisol Parenting Prolactin 00 31 24 How Illness Impacts Testosterone Estrogen Cytokines e g IL-6 00 33 20 How Exactly Do Behaviors Change Hormones 00 34 18 Pheromones Miscarriage Menstrual Cycles Puberty Onset Mate Recognition 00 43 33 Apnea A Powerful Bi-Directional Influence On Estrogen Testosterone 00 47 44 Mouth vs Nose Breathing Hormone Levels Effects Via Sleep and Direct Effects 00 51 11 How Sleep Adjusts Cortisol Testosterone and Cortisol Estrogen Ratios 00 53 49 02 CO2 Ratios Nasal Breathing During Exercise 00 56 30 Light Viewing Patterns Hormones Dopamine GnRH 00 57 44 Spring Fever Tyrosinase Hair Color Mating Frequency 01 04 39 Specificity of Hormone Effects 01 06 03 Temperature Cold Hot Gonads 01 14 10 How To Exercise Types Effort Level Sequencing 01 21 42 Cardio Endurance vs Resistance Training First or Last Yes It Matters 01 24 41 Estrogen Menopause Compounds That May Ameliorate Reverse Symptoms 01 33 18 Nutrients That Optimize The Foundation For Hormones 01 36 00 Opioids as Severe Hormone Disruptors 01 37 23 Testes Antlers Ovaries 01 38 50 Creatine Increasing DHT Dihydrotestosterone 01 40 14 Free and Bound Testosterone SHBG Sex Hormone Binding Globulin Tongat Ali 01 43 23 Nettles Prostate Boron Blood Brain Barrier 01 45 27 Hormone Related Cancers Sometimes Reducing Estrogen and Testosterone Is Optimal 01 47 43 Ecdysteroids Mimic Mammalian Hormones 01 51 50 Optimizing Brain Hormones Chorionic Gonadatropin Fadogia Agrestis 01 57 18 Additional Compounds Liver Toxicity Overall Milieu 01 59 17 Summary And Note About Additional Related Topic Coverage Coming Disclaimer a https 3A 2F 2Fhubermanlab com a disclaimer Title Card Photo Credit Mike Blabac a https 3A 2F 2Fwww blabacphoto com a

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