Dr Zachary Knight The Science of Hunger Medications to Combat Obesity

In this episode my guest is Dr Zachary Knight Ph D a professor of physiology at the University of California San Francisco UCSF and Howard Hughes Medical Institute HHMI investigator We discuss how the brain controls our sense of hunger satiety and thirst He explains how dopamine levels impact our cravings and eating behavior amount food choices etc and how we develop and can change our food preferences and adjust how much we need to eat to feel satisfied We discuss factors that have led to the recent rise in obesity such as interactions between our genes and the environment and the role of processed foods and food combinations We also discuss the new class of medications developed for the treatment of obesity and diabetes including the GLP-1 agonists semaglutide Ozempic Wegovy and tirzepatide Mounjaro We discuss how these medications work to promote weight loss the source of their side effects and the newer compounds soon to overcome some of those side effects such as muscle loss Dr Knight provides an exceptionally clear explanation for our sense of hunger thirst and food cravings that translates to practical knowledge to help listeners better understand their relationship to food food choices and meal size to improve their diet and overall health Access the full show notes including referenced articles books people mentioned and additional resources a https 3A 2F 2Fwww hubermanlab com 2Fepisode 2Fdr-zachary-knight-the-science-of-hunger-medications-to-combat-obesity a Thank you to our sponsors AG1 a https 3A 2F 2Fdrinkag1 com 2Fhuberman a BetterHelp a https 3A 2F 2Fbetterhelp com 2Fhuberman a Eight Sleep a https 3A 2F 2Feightsleep com 2Fhuberman a Waking Up a https 3A 2F 2Fwakingup com 2Fhuberman a LMNT a https 3A 2F 2Fdrinklmnt com 2Fhuberman a Huberman Lab Social Website Instagram a https 3A 2F 2Fwww instagram com 2Fhubermanlab a Threads a https 3A 2F 2Fwww threads net 2F 40hubermanlab a Twitter a https 3A 2F 2Ftwitter com 2Fhubermanlab a Facebook a https 3A 2F 2Fwww facebook com 2Fhubermanlab a TikTok a https 3A 2F 2Fwww tiktok com 2F 40hubermanlab a LinkedIn a https 3A 2F 2Fwww linkedin com 2Fin 2Fandrew-huberman a Website a https 3A 2F 2Fwww hubermanlab com a Newsletter a https 3A 2F 2Fwww hubermanlab com a newsletter Dr Zachary Knight UCSF academic profile a https 3A 2F 2Fprofiles ucsf edu 2Fzachary knight a HHMI profile a https 3A 2F 2Fwww hhmi org 2Fscientists 2Fzachary-knight a Publications a https 3A 2F 2Fknightlab ucsf edu 2Fpublications a Lab website a https 3A 2F 2Fknightlab ucsf edu a X a https 3A 2F 2Fx com 2Fzaknight a Instagram a https 3A 2F 2Fwww instagram com 2Fzknightsf a LinkedIn a https 3A 2F 2Fwww linkedin com 2Fin 2Fzachary-knight-29a37977 a Timestamps 00 00 00 Dr Zachary Knight 00 02 38 Sponsors BetterHelp Helix Sleep Waking Up 00 07 07 Hunger Timescales 00 11 28 Body Fat Leptin Hunger 00 17 51 Leptin Resistance Obesity 00 20 52 Hunger Food Foraging Feeding Behaviors AgRP Neurons 00 30 26 Sponsor AG1 00 32 15 Body Weight Obesity Genes POMC Neurons 00 39 54 Obesity Genetics Environmental Factors 00 46 05 Whole Foods Ultra-Processed Foods Palatability 00 49 32 Increasing Whole Food Consumption Sensory Specific Satiety Learning 00 58 55 Calories vs Macronutrients Protein Salt 01 02 23 Sponsor LMNT 01 03 58 Challenges of Weight Loss Hunger Energy Expenditure 01 09 50 GLP-1 Drug Development Semaglutide Ozempic Wegovy 01 19 03 GLP-1 Drugs Muscle Loss Appetite Reduction Nausea 01 23 24 Pharmacologic Physiologic Effects GLP-1 Drugs Additional Positive Effects 01 30 14 GLP-1-Plus Development Tirzepatide Mounjaro AMG 133 01 34 49 Alpha-MSH Pharmacology 01 40 41 Dopamine Eating Context 01 46 01 Dopamine Learning Water Content Food 01 53 23 Salt Water Thirst 02 03 27 Hunger vs Thirst 02 05 46 Dieting Nutrition Mindset 02 09 39 Tools Improving Diet Limiting Food Intake 02 14 15 Anti-Obesity Drug Development 02 17 03 Zero-Cost Support Spotify Apple Follow Reviews YouTube Feedback Social Media Neural Network Newsletter HubermanLab Health Obesity Title Card Photo Credit Mike Blabac - a https 3A 2F 2Fwww blabacphoto com a Disclaimer a https 3A 2F 2Fwww hubermanlab com a disclaimer

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