Effect of Hormone Imbalances on Energy Sleep Depression Anxiety

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16 Jul 2021

SUBSCRIBE and click the BELL to get notified when new videos are uploaded Unlimited CEUs 59 based on these videos at a https 3A 2F 2Fallceus com a for social work counseling marriage and family therapy addiction counseling case management pastoral counseling and more Want to chat with me Join me at a https 3A 2F 2Fmembers docsnipes com 2F a For 10 month you get access to my tips for health and wellness and you can text chat with me privately Sponsored by TherapyNotes com Manage your practice securely and efficiently Two free weeks of TherapyNotes with coupon code CEU CEUs are available for this presentation at AllCEUs a https 3A 2F 2Fwww allceus com 2Fmember 2Fcart 2Findex 2Fproduct 2Fid 2F1182 2Fc 2F a Want to listen to it as a podcast instead Subscribe to Counselor Toolbox Podcast Estradiol is predominant prior to menopause Estrone is the primary form postmenopausally Synthesized by fatty tissue Estrogen works synergistically with many biological systems to promote physical cognitive and affective function Estrogens can modulate neuronal excitability through serotonin norepinephrine dopamine and endorphin regulation Estrogen supplementation can decreased both systolic and diastolic blood pressures and reduced norepinephrine levels Estrogen Estrogen modulates mood via the serotonergic system Estrogen Estrogen also regulates glucose metabolism and energy production Declines in these processes are characteristic of neurodegenerative diseases Estrogens exert neuroprotective actions to maintain cerebrovasculature health including prevention glutamate-induced excitotoxicity and hippocampal shrinkage Estrogens exert some anti-inflammatory effects Naturally occurring higher levels of estrone were associated with poorer cognition specifically working memory performance Estradiol acts in part through nitric oxide arginine to increase extracellular dopamine levels The Sex Hormones Estrogen Premenopausal females have a better response than males to serotonergic antidepressants indicating female hormones may improve the efficacy of SSRIs Depressed postmenopausal females on supplemental estrogen plus SSRIs showed improved response compared with depressed postmenopausal females without estrogen Estrogen alone did not relieve depression Estrogen and the HPA-Axis Higher levels of Estradiol produced a stronger HPA axis response during non-threatening situations and during and after stressors Under conditions of anxiety and stress women attend to threat differently depending on endogenous estradiol levels being avoidant when estradiol is lower and vigilant when estradiol is higher Estradiol increases the activation of Corticotropin Releasing Hormone and base levels of ACTH Chronic stress produces a hyporesponsive HPA axis that is hypersensitive to the modulating effects of estrogen Changes in 5-HT1A receptor binding in the hippocampus and hypothalamus are restored by estrogen replacement Estrogen and the HPA-Axis Treatment with estradiol could inhibit the negative feedback effects of cortisol increasing cortisol levels Estradiol treatment has been shown to increase corticosteroid binding globulin CBG which inactivates cortisol in males Low estrogen blunted HPA-Axis response depression High estrogen exacerbated HPA-Axis response and sustained higher levels of ACTH anxiety inflammation autoimmune Estrogen and Cognition HT administered at or around the time of menopause may improve cognition but HT initiated five years or more after menopause shows no cognitive benefit Shorter time between menopause and initiation of HT was associated with larger hippocampal volume HT utilizing Estradiol more effectively recalibrates the estradiol estrone ratio to approximate pre-menopausal levels Testosterone Testosterone is essential for maintaining virilization and muscle mass and may also affect libido mood regulation bone health and cardiac disease Hypogonadal men exhibit a significantly higher prevalence of anxiety disorders and major depressive disorder Certain chemotherapies can reduce testosterone and increase anxiety testosterone can enhance dopamine and serotonin release in the mesolimbic system Testosterone can enhance GABA Gonadal dysfunction appears to impair dopamine release but not synthesis important esp for transgender individuals Gonadal steroids impact HPA axis reactivity differentially Testosterone replacement blunts the CORT and ACTH response to stress Estradiol treatment increases the reactivity of the HPA axis To maintain homeostasis the neuroendocrine system continuously monitors the levels of gonadal steroids using estrogen and androgen receptors in the hypothalamus Dysregulation of either or both of these axes can result in compromised responses to stressful life events Testosterone is suppressed with long term opioid use DrDawnEliseSnipes provides Counseling CEUs and training through allceus cheap ce